The role of established breast cancer susceptibility loci in mammographic density in young women.
نویسندگان
چکیده
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, USC/Norris Comprehensive Cancer Center, Los Angeles, California; Institute for Health Promotion and Disease Prevention Research, Keck School of Medicine, University of Southern California, Alhambra, California; City of Hope Comprehensive Cancer Center and Beckman Research Institute, Duarte, California; and Department of Nutrition, University of Oslo, Oslo, Norway
منابع مشابه
Investigating the Factors Affecting the Mammographic Density of Breast Tissue in Patients Referred to the Breast Cancer Research Center, Iran
Introduction: Of the factors leading to false negative results in mammography is breast tissue density, and by increasing the density of breast tissue in mammography, the mammography sensitivity decreases. On the other hand, increasing the breast tissue density leads to increased risk of breast cancer. Various factors such as inheritance, genetics, hormonal and reproductive factors, and nutriti...
متن کاملInvestigating the Factors Affecting the Mammographic Density of Breast Tissue in Patients Referred to the Breast Cancer Research Center, Iran
Introduction: Of the factors leading to false negative results in mammography is breast tissue density, and by increasing the density of breast tissue in mammography, the mammography sensitivity decreases. On the other hand, increasing the breast tissue density leads to increased risk of breast cancer. Various factors such as inheritance, genetics, hormonal and reproductive factors, and nutriti...
متن کاملبررسی نقش سونوگرافی تکمیلی در تشخیص سرطان پستان
Introduction & Objective: The breast cancer is the most common malignancy in women and in recent years it is seen in younger ages. Because of dense breast tissue in these ages, the mammography sensitivity for breast cancer detection is reduced, so high quality ultrasonography (US) as a combined screening method is effective. The aim of this study is the evaluation of the mammographic finding ...
متن کاملVolumetric mammographic density: heritability and association with breast cancer susceptibility loci.
BACKGROUND Mammographic density is a strong heritable trait, but data on its genetic component are limited to area-based and qualitative measures. We studied the heritability of volumetric mammographic density ascertained by a fully-automated method and the association with breast cancer susceptibility loci. METHODS Heritability of volumetric mammographic density was estimated with a variance...
متن کاملCommon breast cancer susceptibility variants in LSP1 and RAD51L1 are associated with mammographic density measures that predict breast cancer risk.
BACKGROUND Mammographic density adjusted for age and body mass index (BMI) is a heritable marker of breast cancer susceptibility. Little is known about the biologic mechanisms underlying the association between mammographic density and breast cancer risk. We examined whether common low-penetrance breast cancer susceptibility variants contribute to interindividual differences in mammographic den...
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ورودعنوان ژورنال:
- Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
دوره 17 1 شماره
صفحات -
تاریخ انتشار 2008